Non-myogenic Contribution to Muscle Development and Homeostasis: The Role of Connective Tissues - Archive ouverte HAL Access content directly
Journal Articles Frontiers in Cell and Developmental Biology Year : 2017

Non-myogenic Contribution to Muscle Development and Homeostasis: The Role of Connective Tissues

(1) , (1) , (1)
1

Abstract

Skeletal muscles belong to the musculoskeletal system, which is composed of bone, tendon, ligament and irregular connective tissue, and closely associated with motor nerves and blood vessels. The intrinsic molecular signals regulating myogenesis have been extensively investigated. However, muscle development, homeostasis and regeneration require interactions with surrounding tissues and the cellular and molecular aspects of this dialogue have not been completely elucidated. During development and adult life, myogenic cells are closely associated with the different types of connective tissue. Connective tissues are defined as specialized (bone and cartilage), dense regular (tendon and ligament) and dense irregular connective tissue. The role of connective tissue in muscle morphogenesis has been investigated, thanks to the identification of transcription factors that characterize the different types of connective tissues. Here, we review the development of the various connective tissues in the context of the musculoskeletal system and highlight their important role in delivering information necessary for correct muscle morphogenesis, from the early step of myoblast differentiation to the late stage of muscle maturation. Interactions between muscle and connective tissue are also critical in the adult during muscle regeneration, as impairment of the regenerative potential after injury or in neuromuscular diseases results in the progressive replacement of the muscle mass by fibrotic tissue. We conclude that bi-directional communication between muscle and connective tissue is critical for a correct assembly of the musculoskeletal system during development as well as to maintain its homeostasis in the adult.
Fichier principal
Vignette du fichier
2017 revue CT.pdf (1.49 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

hal-01539045 , version 1 (14-06-2017)

Identifiers

Cite

Claire Fournier-Thibault, Sonya Nassari, Delphine Duprez. Non-myogenic Contribution to Muscle Development and Homeostasis: The Role of Connective Tissues. Frontiers in Cell and Developmental Biology, 2017, 1, pp.22 - 22. ⟨10.3389/fcell.2017.00022⟩. ⟨hal-01539045⟩
211 View
311 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More