The Synthesis of Dialkyl α-Halogenated Methylphosphonates

Rachel Waschbüsch (1) , John Carran (1) , Angela Marinetti (1) , Philippe Savignac (1)

1 DCPH - Laboratoire Hétéroéléments et Coordination

This article reviews the main synthetic approaches to mono-, di- and trihalogenated methylphosphonates containing fluorine, chlorine, bromine and iodine. It includes some general, widely used methods, such as the Michaelis-Arbuzov, Michaelis-Becker, Kinnear-Perren and Kabachnik reactions, as well as more specific approaches such as oxidative or reductive procedures. Representative experimental procedures are described for each type of compound.

Domaines: Chimie organique

Rachel Waschbüsch, John Carran, Angela Marinetti, Philippe Savignac. The Synthesis of Dialkyl α-Halogenated Methylphosphonates. Synthesis: Journal of Synthetic Organic Chemistry, 1997, 1997 (07), pp.727-743. ⟨10.1055/s-1997-1417⟩. ⟨hal-03166421⟩