Dialkyl 1-Alkynylphosphonates: A Range of Promising Reagents

Bogdan Iorga (1) , Frédéric Eymery (1) , Duncan Carmichael (1) , Philippe Savignac (1)

1 DCPH - Laboratoire Hétéroéléments et Coordination

The present review covers the preparations of 1-alkynylphosphonates by Michaelis-Arbuzov and Michaelis-Becker reactions, nucleophilic substitutions at phosphorus (SNP(V)) and elimination from 1-alkenylphosphonates. Their reactivity and versatility have made them valuable precursors for other phosphonates and particularly for the synthesis of heterocycles by [2+2], [3+2] and [4+2] cycloaddition reactions.

Domaines: Chimie

Bogdan Iorga, Frédéric Eymery, Duncan Carmichael, Philippe Savignac. Dialkyl 1-Alkynylphosphonates: A Range of Promising Reagents. European Journal of Organic Chemistry, 2000, 18, pp.3103-3115. ⟨10.1002/1099-0690(200009)2000:18<3103::aid-ejoc3103>3.0.co;2-v⟩. ⟨hal-03161491⟩