Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity - Université Nice Sophia Antipolis Accéder directement au contenu
Article Dans Une Revue Molecular Psychiatry Année : 2018

Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity

S. Parnaudeau
F. Tronche

Résumé

Epidemiological studies report strong association between mood disorders and tobacco addiction. This high comorbidity requires adequate treatment but the underlying mechanisms are unknown. We demonstrate that nicotine exposure, independent of drug withdrawal effects, increases stress sensitivity, a major risk factor in mood disorders. Nicotine and stress concur to induce long-lasting cellular adaptations within the dopamine (DA) system. This interplay is underpinned by marked remodeling of nicotinic systems, causing increased ventral tegmental area (VTA) DA neurons' activity and stress-related behaviors, such as social aversion. Blocking β2 or α7 nicotinic acetylcholine receptors (nAChRs) prevents, respectively, the development and the expression of social stress-induced neuroadaptations; conversely, facilitating α7 nAChRs activation specifically in the VTA promotes stress-induced cellular and behavioral maladaptations. Our work unravels a complex nicotine-stress bidirectional interplay and identifies α7 nAChRs as a promising therapeutic target for stress-related psychiatric disorders.
Fichier principal
Vignette du fichier
mp2017145.pdf (4.19 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-02182455 , version 1 (12-07-2019)

Identifiants

Citer

C. Morel, S P Fernandez, F Pantouli, F. J Meye, F. Marti, et al.. Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity. Molecular Psychiatry, 2018, 23 (7), pp.1597-1605. ⟨10.1038/mp.2017.145⟩. ⟨hal-02182455⟩
103 Consultations
66 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More