Assessment of the efficacy of a local steroid rescue treatment administered 2 days after a moderate noise-induced trauma in guinea pig - Réhabilitation Chirurgicale mini-Invasive et Robotisée de l'Audition Accéder directement au contenu
Article Dans Une Revue Acta Oto-laryngologica Année : 2018

Assessment of the efficacy of a local steroid rescue treatment administered 2 days after a moderate noise-induced trauma in guinea pig

Résumé

Objectives : Intratympanic injection of corticosteroids membrane after noise-induced hearing loss is an accepted alternative to general administration. We investigated the effect on hearing of a hyaluronic acid gel with liposomes loaded with dexamethasone (DexP) administered into the middle ear. Methods : An acute acoustic trauma was performed to 13 guinea pigs for a period of 1 h on Day −2. Two 2 days after the noise trauma, the animals were then assigned randomly to four experimental groups: control without gel, gel injection, gel-containing free DexP, gel-containing DexP loaded into liposomes. Auditory thresholds were measured with Auditory Brainstem Response before Day −2 and at Day 0, Day 7 and Day 30 after noise trauma. Results : Seven days after, a complete hearing recovery was observed in the control group at all frequencies apart from 8 kHz, and no recovery was observed in the three groups receiving a gel injection. Thirty days after trauma, all of the animals had recovered normal hearing, apart from at the 8-kHz frequency, with similar auditory thresholds. Conclusions : Local DexP administration 48 h after a mild acoustic trauma did not improve hearing recovery, even with a sustained release in a specific gel formulation designed for inner ear therapy.
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Dates et versions

hal-02111940 , version 1 (17-05-2019)

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Elisabeth Mamelle, Naila El Kechai, Victor Adenis, Yann Nguyen, Olivier Sterkers, et al.. Assessment of the efficacy of a local steroid rescue treatment administered 2 days after a moderate noise-induced trauma in guinea pig. Acta Oto-laryngologica, 2018, 138 (7), pp.610-616. ⟨10.1080/00016489.2018.1438659⟩. ⟨hal-02111940⟩
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