Ultrasmall particles for Gd-MRI and 68Ga-PET dual imaging

Charles Truillet (1) , Penelope Bouziotis (2) , Charalambos Tsoukalas (2) , Jérémy Brugière (1) , Matteo Martini (1) , Lucie Sancey (1) , Thomas Brichart (1) , Franck Denat (3) , Frédéric Boschetti (4) , Ulrich Darbost (5) , Isabelle Bonnamour (5) , Dimitris Stellas (6) , Constantinos D. Anagnostopoulos (7) , Vassilis Koutoulidis (8) , Lia A. Moulopoulos (8) , Pascal Perriat (9) , François Lux (1) , Olivier Tillement (1)

1 ILM - Institut Lumière Matière [Villeurbanne]
2 NCSR - National Center for Scientific Research "Demokritos"
3 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]
4 CheMatech - Macrocycle Design Technologies
5 CSAP - Chimie Supramoléculaire Appliquée
6 Department of Cancer Biology
7 Center for Experimental surgery, Clinical and Translational Research
8 Department of Radiology
9 MATEIS - Matériaux, ingénierie et science [Villeurbanne]

Nanoparticles made of a polysiloxane matrix and surrounded by 1,4,7,10-tetraazacyclododecane-1-glutaric anhydride-4,7,10-triacetic acid (DOTAGA)[Gd3+] and 2,2'-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid) NODAGA[68Ga3+] have been synthesized for positron emission tomography/magnetic resonance (PET/MRI) dual imaging. Characterizations were carried out in order to determine the nature of the ligands available for radiolabelling and to quantify them. High radiolabelling purity (>95%) after 68Ga labelling was obtained. The MR and PET images demonstrate the possibility of using the nanoparticles for a combined PET/MR imaging scanner. The images show fast renal elimination of the nanoparticles after intravenous injection.Copyright © 2014 John Wiley & Sons, Ltd.

Mots clés: multimodal imaging; PET/MRI; nanoparticles

Domaines: Imagerie

Charles Truillet, Penelope Bouziotis, Charalambos Tsoukalas, Jérémy Brugière, Matteo Martini, et al.. Ultrasmall particles for Gd-MRI and 68Ga-PET dual imaging. Contrast Media and Molecular Imaging, 2014, 10 (4), pp.309-319. ⟨10.1002/cmmi.1633⟩. ⟨hal-01115872⟩