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Enhancing the biodegradation efficiency of a emergent refractory water pollutant by a bacterial isolate through a statistical process optimization approach

Abstract : Clofibric acid, the main pharmacologically-active metabolite of pharmaceutical products used as antilipaemic agent has received, in last years, an increased interest because of its well-known recalcitrance to biodegradation and its high persistence in the aquatic environment. This molecule passes unchanged or poorly transformed in wastewater treatment plants. An indigenous strain of Streptomyces, named MIUG 4.89 was previously selected, exhibited the ability to favor clofibric acid biodegradation within submerged cultivation in controlled biotechnological conditions. Thus, in order to enhance the biodegradation of this refractory molecule, mathematical modeling and statistical optimization designs associated to Plackett-Burman Design and Response Surface Methodology were used to evaluate and optimize the effects of different major culture conditions of this bacterial isolate. According to the results, under optimized culture conditions (5 g L−1 glucose, inoculation level 4.7 %, 27.5 °C and 20 days of incubation) the strain Streptomyces MIUG 4.89 exhibited a successful removal of clofibric acid with a biodegradation yield of 54 %, which is in agreement with model prediction. Thus, under optimized conditions, the removal yield was enhanced, which is very promising accounting for the refractory character of this water pollutant.
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https://hal.archives-ouvertes.fr/hal-03196088
Contributor : Laurent Jonchère <>
Submitted on : Friday, April 16, 2021 - 4:01:26 PM
Last modification on : Tuesday, April 20, 2021 - 2:37:21 PM

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Lidia Favier, C.V. Ungureanu, A.I. Simion, G.-E. Bahrim, Christophe Vial. Enhancing the biodegradation efficiency of a emergent refractory water pollutant by a bacterial isolate through a statistical process optimization approach. Process Safety and Environmental Protection, Elsevier, 2021, 148, pp.1133-1145. ⟨10.1016/j.psep.2021.02.012⟩. ⟨hal-03196088⟩

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