Skip to Main content Skip to Navigation
Journal articles

Nucleolus: A Central Hub for Nuclear Functions

Abstract : The nucleus contains distinct nuclear bodies (NBs); nucleolus is the largest and the most studied NB, but its role in the functioning of the nucleus is far from being fully understood. The nucleolus is not surrounded by a membrane, yet it contains DNA, RNA and a set of proteins that can either be retained in the nucleolus or rapidly shuttle between the nucleoplasm, the nucleolus and the cytoplasm in response to various stimuli. The emerging evidence points to the central function of the nucleolus in organizing many nuclear functions besides RNA polymerase I transcription and ribosome biogenesis. Here we discuss the functions of the nucleolus related to the shuttling of proteins and nucleic acids between nucleolus and nucleoplasm. The functional processes affected by shuttling of nucleolar components include 3D organization of the genome, stress response, DNA repair and recombination, transcription regulation, telomere maintenance and other essential cellular functions.
Document type :
Journal articles
Complete list of metadatas

Cited literature [237 references]  Display  Hide  Download
Contributor : Yegor Vassetzky <>
Submitted on : Wednesday, November 18, 2020 - 3:23:42 PM
Last modification on : Wednesday, November 18, 2020 - 5:47:21 PM


TCB-D-18-00157_R1 (1).pdf
Files produced by the author(s)




Olga Iarovaia, Elizaveta Minina, Eugene Sheval, Daria Onichtchouk, Svetlana Dokudovskaya, et al.. Nucleolus: A Central Hub for Nuclear Functions. Trends in Cell Biology, Elsevier, 2019, 29 (8), pp.647-659. ⟨10.1016/j.tcb.2019.04.003⟩. ⟨hal-02322927⟩



Record views


Files downloads